Abstract: Natural polyphenols are a kind of organic compounds containing oxygen heterocycles,which are widely distributed in nature word.They are rich in foods,vegetables and fruits closely related to human daily life and have a variety of physiological activities,such as anti-oxidation,anti-atherosclerosis,anti-infection,anti-tumor and anti-osteoporosi.Natural polyphenols have attracted worldwide attention in maintaining homeostasis and preventing and treating certain diseases.They are important active components of natural medicines.However,polyphenols have some toxic and side effects in the process of human metabolism,which may restrictclinical use.Therefore,the safety of polyphenol compounds should be tested and evaluated to determine the corresponding safe dose.

Key words: natural polyphenols, chemical compound, pharmacology, antineoplastic agents