Abstract: This study was performed to evaluate the influence of Qisang hypoglycemic formula (Q-S,1.0 g/kg and 0.5 g/kg) on blood glucose and liver function of type 2 diabetic mellitus rats induced by high-glucose-fat diet and low dose of STZ (35 mg/kg).The results showed that Q-S significantly decreased the levels of FBG,GP,ALT,AST,GSP and MDA compared with the diabetic mellitus model control group (P<0.01).Meanwhile,it was found that the levels of ISI,GS,SOD and GSH-PX were remarkably higher than that of the diabetic mellitus model control group (P<0.05, P<0.01).In conclusion,Q-S had an significant effect of lowering blood sugar on diabetic mellitus rats,and can improve the liver function simultaneously.

Key words: Qisang hypoglycemic formula, diabetes mellitus, STZ, FBG, liver function