NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2018, Vol. 30 ›› Issue (3): 475-479. doi: 10.16333/j.1001-6880.2018.3.021

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Pharmacokinetic Study on Active Ingredients of Shenfu Injection in Normal and Chronic Heart Failure Rats

LI Yan, DANG Jue, CAO Xiao-yu, LI Yun-xia*, PENG Cheng*   

  1. Pharmacy College,Chengdu University of Traditional Chinese Medicine,The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine,State Key Laboratory Breeding Base of Systematic Research,Development and Utilization of Chinese Medicine Resources Co-founded by Sichuan Province and MOST,Chengdu 611137,China
  • Online:2018-04-08 Published:2018-04-08

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Abstract: To compare the pharmacokinetics of active ingredients of five ginsenosides in Shenfu Injection in normal and chronic heart failure rats.Six SD rats were given doxorubicin hydrochloride to establish the model of chronic heart failure as the model group.Another six SD rats were given isometric normal saline as the control group.Shenfu Injection was given to rats of each group,respectively.After preparation of plasma samples,the plasma concentration of five kinds of ginsenosides was determined by means of UPLC-DAD method.The pharmacokinetic parameters were calculated by WinNonlin6.3 software,and then it was compared.The results showed that the Cmax  and AUC last of ginsenoside Rg1,Re,Rb1,Rc and Rd were significantly higher in the model group than that in the normal group after administration.Compared with the normal group,the Cl/F was significantly decreased in the model group,and the difference was statistically significant (P<0.05).The pharmacokinetic characteristics of five ginsenosides of Shenfu Injection in rats in vivo can be affected by chronic heart failure.

Key words: Shenfu Injection, active ingredients, ginsenosides, chronic heart failure, pharmacokinetics

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