Abstract: The purpose of the present study was to examine the effects of Citronella oil extract on hemorheology and coagulation function in acute blood-stasis model rats.Acute blood stasis syndrome was induced by placing the rats in ice-cold water following injections with epinephrine.The hemorheological indicators,blood coagulation indicators,and platelet maximum aggregation were measured.We found that whole blood viscosity,plasma viscosity,whole blood low-cut relative viscosity,whole blood high-cut relative viscosity,erythrocyte aggregation index,platelet accumulation rate,fibrinogen (FIB) and activated partial thromboplastin time (APTT) were significantly increased,thrombin time (TT) and prothrombin time (PT) were significantly decreased in acute blood stasis model group.However,treatment with citronella oil extract significantly increased the whole blood viscosity,plasma viscosity,whole blood low-cut relative viscosity,whole blood high-cut relative viscosity,erythrocyte aggregation index,platelet accumulation rate,FIB and APTT,and decreased PT and TT.Overall,the results of the present study suggested that citronella oil extract can significantly improve the hemorheology and coagulation function in acute blood stasis syndrome rats.

Key words: citronella oil extract, acute blood stasis model, coagulation function, hemorheology