Abstract: The antimalarial activity of artemisinin and its derivatives had been recognized worldwide.Its main derivatives include dihydroartemisinin,artemether,artemether,artesunate and so on.Modern pharmacological studies had shown that artemisinin and its derivatives,besides antimalarial activity,had antitumor,anti-inflammatory,immunomodulatory and antiviral effects,and had potential clinical value.However,artemisinin and its derivatives had disadvantages of poor water solubility,short half-life and low bioavailability,which hinder their clinical application.The research showed that the use of modern new drug delivery system and preparation technology can increase the solubility and stability of artemisinin and its derivatives,ameliorate the bioavailability,improve the clinical drug application in medical field.This article had consulted the domestic and foreign literature in recent twenty years.The related literature of artemisinin and its derivatives preparation technology and new drug delivery system were classified and summarized,hoping to provide some reference value for the research and development of drugs and future clinical application.

Key words: artemisinin, artemisinin derivatives, preparation technology, new drug delivery system