NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2018, Vol. 30 ›› Issue (增刊2): 167-172.

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Polysaccharide Extracts and Lutein Ameliorate Light-induced Retinal Damage in Pigmented Rabbit

MENG Lu-xi1,2,4,5,6,YU Qing-tao3,4,HUANG Feng-hong1,2,4,5,6,GE Ya-zhong3,4,JIN Xin3,4,TANG Jian3,4,ZANG Xi-xi1,2,4,5,6,CHEN Peng1,2,4,5,6,DENG Qian-chun1,2,4,5,6*   

  1. 1Oil Crops Research Institute,Chinese Academy of Agricultural Sciences; 2Hubei Key Laboratory of Lipid Chemistry and Nutrition,Wuhan 430062,China; 3Infinitus (China) Co.,Ltd.,Guangzhou 510623,China; 4Joint Laboratory of functional lipids research-Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences and Infinitus; 5Key Laboratory of oil processing of Ministry of Agriculture; 6 Oil crops and Lipids Process Technology National & Local Joint Engineering Laboratory,Wuhan 430062,China
  • Online:2019-01-18 Published:2019-01-18

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Abstract: To explore the protective effects of polysaccharide extracts and lutein against light-induced retinal damage in pigmented rabbit.The visual functions,caspase3 expression and antioxidant activity were evaluated in different dose of polysaccharide extract and lutein-treated rabbit after light exposure.Results showed that light exposure induced significant retinal damage in Rabbit when compared with normal control.Polysaccharide extracts and lutein administration at middle and high dose levels evidently improved retinal response to light and dark adaptation,increased the outer nuclear layer (ONL) thickness by 25.78% and 28.21%,and suppressed the caspase 3 expression by 84.08% and 89.64% (P<0.05).Furthermore,polysaccharide extracts and lutein partially reversed light-overwhelmed retinal oxidative stress with decreased IL-1β and VEGF content (P<0.05).All indicated dietary middle and high-dose of polysaccharide extracts and lutein protected light-induced retinal damage through suppressing rods,cones and photoreceptor cell apoptosis and inhibition of inflammatory cytokine production.

Key words: polysaccharide extracts, lutein, pigmented rabbit, retinal light damage, protective effect

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