Abstract: Triterpenoid saponins are one of the main active components in radix Bupleuri.Their hepatoprotective effect have gained extensive attention of many researchers.It has been found that saikosaponins have estrogenic-like effects.They can protect the liver by reducing hepatocyte damage,as well as inhibit the activation and proliferation of hepatic stellate cells,and subsequently inhibit hepatic fibrosis.They have potential anti-inflammatory,anti-viral and anti-tumor effects,and they can also increase the liver targeting effect and the radiosensitivity of hepatocarcinoma cells in combination therapy.This article reviews the latest research progress on the hepatoprotective mechanism of saikosaponins,aiming to provide literature basis and research ideas for further exploring the clinical application of saikosaponins and guiding the design and development of new drugs for liver diseases.

Key words: Bupleurum species, triterpenoid saponin, liver fibrosis, pharmacological effect