Abstract: The nematodes were seriously endangered.It not only brought serious diseases to humans,animals and plants,but also brought huge economic losses to the livestock industry.At present,the main methods for controlling diseases caused by nematodes are the use of insect repellents and chemotherapy,but as the drug resistance of these drugs continues to increase,the treatment effect becomes very poor.In recent years,with the increase of human environmental awareness,the prevention and control of nematodes has become a key issue and focus.Therefore,a new treatment method is needed to replace the traditional method,so more and more people are paying attention to the secondary metabolites of the strain.Research and development,and this biocontrol agent is a low-toxic,environmental friendly method and an effective means to achieve green prevention and control.This article reviews the secondary metabolites produced by some nematophagous organisms.

Key words: nematophagous fungi, secondary metabolites, drug resistance, biological control agents