Abstract: The study was focus on the phenolic compounds of Harrisonia perforata(Blanco) Merr.and their antioxidant activity.Fourteen compounds were isolated from the branches of Harrisonia perforata(Blanco) Merr.by various column chromatography.Their structures were identified as noreugenin (1),saikochromone A (2),5,7-dimethoxy-2-methylchromone (3),2-hydroxymethylalloptaeroxylin (4),ethylparaben (5),propiophenone (6),cephafortin B (7),dehydroconiferyl alcohol (8),hawthornnin C (9),hawthornnin D (10),syringaresinol (11),medioresinol (12),4-ketopinoresinol (13)and matairesinol (14)based on ESI-MS,¹H and ¹³C NMR spectroscopic data.Among them,compound 1,3,5-10,and 12-13 were isolated from this plant for the first time.In addition,DPPH radical scavenging method was used to evaluate antioxidant activity,compound 13 and 14 showed strong DPPH free radical scavenging capacity.And then,we discussed the structure activity relationship of these phenolic compounds.The results provided a theoretical basis for deep development and utilization of Harrisonia perforata(Blanco) Merr.

Key words: Harrisonia perforata(Blanco) Merr., chemical constituents, phenolic compounds, antioxidant activity, structure activity relationship