Study on the mechanism of anti-atherosclerosis effect of Cydonia Oblanga Mill. in Xinjiang based on network pharmacology

doi:10.16333/j.1001-6880.2019.10.017

Abstract

Abstract: To study the active compounds and their targets of Xinjiang Cydonia Oblanga Mill.(COM) by network pharmacological method,and to construct a component-target-pathway network to explore its anti-atherosclerosis “multi-components,multi-targets,multi-pathways” mechanism.Ten main active compounds related to atherosclerosis were collected from different databases,and 10 main targets were predicted,which involved in the biological functions of vascular smooth muscle cell proliferation,white adipocyte differentiation,and participated in PPAR signaling pathways,reflecting the multi-components,multi-targets and multi-pathways mechanism of COM.The characteristics provide a scientific basis for explaining the mechanism of atherosclerosis.

Key words: network pharmacology, Cydonia Oblanga Mill., atherosclerosis, active compound, target of action

CLC Number:

R966

SIMAYI Jimilihan1,WUMAIER Ainiwaer1,YUSUFU Maierdan1,SAWUTI Adilijiang1,NUERMAIMAITI Maimaitiming2,ZHOU Wen-ting1*. Study on the mechanism of anti-atherosclerosis effect of Cydonia Oblanga Mill. in Xinjiang based on network pharmacology[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2019, 31(10): 1783-1790.

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Study on the mechanism of anti-atherosclerosis effect of Cydonia Oblanga Mill. in Xinjiang based on network pharmacology

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