Abstract: Sesquiterpenoid dimers are one class of structurally complex constituents in the family of Compositae.In recent years,they have become a hotspot in the field of natural product chemistry.In this paper,sesquiterpenoid dimers were classified into different groups based on the ways of connection of the two sesquiterpnoid monomers,i.e.cyclization,ester bond or C-C bond.Pharmacological studies have shown that these chemical constituents have significant activities in anti-inflammation,anti-tumor and neuroprotection.This review covered 143 sesquiterpenoid dimers and their biological activities reported from 2011 to 2018,which might serve as a reference for further research and investigations.

Key words: Compositae, sesquiterpenoid dimer, connectivity, biological activities