Abstract: In order to investigate the chemical constituents and neuroprotective effects of the water soluble of the Buddleja lindleyana fruits,10 compounds were isolated from water soluble of the Buddleja lindleyana fruits by various chromatographic separation techniques.By NMR and documents,the structures of the isolated compounds were identified as scleroside C (1),isoflavulinin (2),verbascoside (3),4′-hydroxyphenyl ethyl vanillate (4),6-O-vanillylsclerotin (5),syringaresinol-4′-O-β-D-glucopyranoside (6),acanthopanax B (7),cypressin (8),saponinⅣb (9),6-O-(3"-O-p-coumaroyl-α-L-rhamnopyranosyl)catalpol (10).Compounds 4,6,7,8,10 were isolated from the genus Buddleia for the first time,and compounds 2 and 3 were isolated from the fruit of Buddleja lindleyana for the first time.Neuroprotective effects of compounds 1,5,6 and 7 were screened by MPP⁺-induced SH-SY5Y cell model,and results showed that all four compounds could significantly improve cell viability.

Key words: Buddleja lindleyana fruits, water-soluble fraction, chemical constituents, neuroprotective