Abstract: This research is aimed to investigate the effect of chondroitin sulphate (CS) feeding on mice hypolipidemic performance.The hyperlipidemia model mice were fed with CS of the low dose (0.1 g/d),the medium dose (0.5 g/d) and the high dose (2.5 g/d) respectively to study the variation of mice body weight (W),the concentration of total cholesterol (TC),triglyceride (TG),low density lipoprotein (LDL) and high density lipoprotein (HDL) in the mice blood.The result shows that low dose CS and medium dose CS feeding exhibit no significant effects on the variation of the hyperlipidemia model mice body weight (P＞0.05),while high dose CS exhibit the significant effect on the decreasing of the mice body weight (P＜0.05).Low doses CS had no significant effect on the concentration of TC,TG and LDL in the mice blood (P＞0.05),while high doses could significantly decrease the concentration of TC,TG and LDL in the mice blood(P＜0.05),but low doses,medium and high doses significantly increase the HDL concentration(P＜0.05).To summarise,CS has a positive hypolipidemic function in hyperlipidemic mice.

Key words: chondroitin sulfate, total cholesterol, triglycerides, low density lipoprotein, high density lipoprotein, Conquer the blood grease