The effect of Huangqi compound on collagen and MMP in fibroblasts

doi:10.16333/j.1001-6880.2019.S.013

NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2019, Vol. 31 ›› Issue (增刊2): 84-87.doi: 10.16333/j.1001-6880.2019.S.013

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The effect of Huangqi compound on collagen and MMP in fibroblasts

WANG Feng-lou1,DENG Wen-juan2,HE Gai-ying1*

1LB Cosmeceutical Technology Co.,Ltd,Shanghai 200233,China; 2Infinitus Company Ltd.,Guangzhou 510663,China

Online:2019-12-28 Published:2019-12-30

Abstract

Abstract: The effect of Huangqi compound on collagen type I,III,extracellular matrix metalloproteinase(MMP)-1 and -3 in aging fibroblasts induced by H₂O₂.The experimental results showed that collagen type I and III mRNA were significantly decreased,and MMP-1 and MMP-3 mRNA was significantly increased in model group.Collagen type I and III mRNA were significantly increased by Huangqi compound in aging fibroblasts,at the same time,MMP-1 and MMP-3 mRNA were reduced.The study showed that Huangqi compound had the effect of anti-aging.

Key words: Huangqi compound, fibroblast, collagen typeⅠ, collagen type Ⅲ , extracellular matrix, metalloproteinase-1, extracellular matrix metalloproteinase-3

WANG Feng-lou1,DENG Wen-juan2,HE Gai-ying1*. The effect of Huangqi compound on collagen and MMP in fibroblasts[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2019, 31(增刊2): 84-87.

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The effect of Huangqi compound on collagen and MMP in fibroblasts

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