The slaughterhouse generates millions of tons of wastes such as feathers,horns and horns each year.These wastes require a lot of land for storage,ash treatment and emission control which pose a serious risk of pollution to the air and groundwater in the environment.The keratin in feathers,horns,horns wastes has the structural characteristics of insolubility and high mechanical stability.It is not easily degraded by ordinary proteases and chemical catalysts.The keratin is difficult to be degraded into polypeptides because the cross-linked disulfide bond exists in it.This review introduces various aspects of keratin solubilization,the effects of keratinase hydrolysis conditions and enzymatic hydrolysis after keratin denaturation treatment.Thus,the keratin waste from slaughter is developed and reused as green and sustainable industrial materials,which can be used in traditional textile,leather,washing and medical industries.