This article aims to analyze the mechanism of Shenfu Injection in the treatment of COVID-19 combined with AKI through network pharmacology and molecular docking methods,and provide theoretical guidance for the treatment of COVID-19 combined with AKI in Chinese medicine.Obtain the chemical composition of red ginseng and aconite in Shenfu Injection through TCMSP database and supplement it with literature;Use the Swiss Target Prediction database to predict the targets of active chemical ingredients;use the GeneCards database to screen the targets of COVID-19 and comorbid AKI;The enrichment analysis of GO and KEGG was carried out through the DAVID database;the Chinese medicine-component-target-channel network was constructed using Cytoscape 3.8.0 software;AutoDock 4.2.6 and PyMol were used for the molecular docking and visualization of the core components with Mpro and ACE2.As a result,139 active ingredients in Shenfu Injection were excavated.There are 64 common targets for Shenfu Injection in the treatment of COVID-19 and AKI.The key targets involve TNF,IL6,MAPK3,CASP3,etc,involving 67 signaling pathways such as hypoxia-inducible factor-1,tumor necrosis factor,PI3K-Akt,Toll-like receptor,and apoptosis.The results of molecular docking showed that ginsenoside-Rc and ACE2,as well as ginsenoside Rh2 and Mpro had better binding ability.This study reveals that Shenfu Injection can treat COVID-19 combined with AKI through multiple components,multiple targets,and multiple pathways to play a role in combating cytokine storm,improving body immunity,resisting oxidative stress and reducing hypoxia-reoxygenation injury.Network pharmacology molecular mechanism.