Abstract: In order to study the effect of a compound,which comprises fish skin collagen peptide,chitosan oligosaccharide (COS),Panax ginsengextract,Astragalus extract and Angelica extract,on the mice immunity,we divided the 336 SPF healthy ICR female mice into four batches(N= 84) randomly.And the cellular immune function,organ/body weight ratio and humoral immune,monocyte-macrophage function and NK cell activity of mice were studied respectively.Each batch was divided into seven groups(n= 12),including negative control group,low-dose(0.5 g/kg),medium-dose(1.0 g/kg) and high-dose compound products group (3.0 g/kg),low-dose (0.5 g/kg),medium-dose(1.0 g/kg) and high-dose fish skin collagen peptide group(3.0 g/kg).Functional indexes were measured according to the daily continuous oral gavage for 30 days.As a result,compared with the negative control group,there were no significant differences in delayed allergy(DTH),organ/body weight ratio,and the number of antibody-producing cells between the experimental groups(P> 0.05).The proliferation ability of lymphocyte,serum hemolysin level and carbon clearance index of monocyte- macrophage were significantly enhanced in compound products group,and the effect of compound on mice immunity was better than that in the fish skin collagen peptide group.In a nutshell,the compound product of fish skin collagen peptide in this study has a better effect on enhancing the mouse immunity than fish skin collagen peptide group.

Key words: fish skin collagen peptide, compound products, mice, immune function