NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2020, Vol. 32 ›› Issue (3): 532-539. doi: 10.16333/j.1001-6880.2020.3.024

• Article • Previous Articles    

Research progress on structural modifications,biological activities and structure-activity relationships of micheliolide

ZHAO Ru,ZENG Bing-lin,PAN Xian-dao*   

  1. Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China
  • Online:2020-03-28 Published:2020-05-12

Abstract: Micheliolide is a sesquiterpene lactone isolated from various natural plants and has lots of biological activities.In recent years,a wide range of micheliolide derivatives have been synthesized by structural modifications with valuable activities.In this review,we will highlight the advances in mechanism of action,structural modifications,biological activities and structure-activity relationships of micheliolide.

Key words: micheliolide, mechanism of action, derivatives, biological activities, structure-activity relationship

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