NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2021, Vol. 33 ›› Issue (2): 223-226.

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Two new sesquiterpene from stems and leaves of Aphanamixis polystachya

QIN Tian-li, CHEN Yan-wu, WU Shi-li, ZHANG Fan, LI Ming-ming, HE Hong-ping   

  1. 1College of Traditional Chinese Medicine，Yunnan University of Chinese Medicine；2College of Chinese National Medicine，Yunnan University of Chinese Medicine，Kunming 650500，China
  • Online:2021-02-28 Published:2021-03-03

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Abstract:

To investigate the chemical constituents of the branches and leaves of Aphanamixis polystachya.Nine compounds were isolated from the 95% ethanol extract of A. polystachya by various column chromatography involving silica gel,Sephadex LH-20 gel,RP-C18and HPLC.Their structures were identified by chemical properties and spectroscopic analyses，and were elucidated as polystachyadione A (1),polystachyadione B (2),labd-13(E)-ene-8α,15-diol (3),labd-13(E)-ene-8α,15-yl acetate(4),1S,4S,5S,10R-4,10-guaianediol (5),oleanolic acid (6),3,4-dihydroxybenzoic acid (7),caffeic acid (8) and α-monopalmitin (9),of which compounds 1 and 2 are new.Compounds 4,7,8 and 9 are obtained from this plant for the first time.The activity tests showed that compounds 1 and 2 have no significant inhibition against NO production.