To explore the mechanism of different parts of M. alba in prevention and treatment of diabetes by network pharmacology and molecular docking.The component information of Folium Mori,Fructus Mori and Ramulus Mori in different parts of Morus alba L.was obtained from TCMSP,TCMID and other traditional Chinese medicine databases.Diabetes target information was obtained by combining OMIM,TTD and other disease databases.The complex network and topology analysis of "active ingredients-disease target" in different parts were constructed by using the software of Cytoscape 3.7.2,and the pathway enrichment was analyzed by WebGestalt tool.Autodock Vina software was used to conduct molecular docking between the main active components and the target of M. alba.Results there were 11 active components in different parts of M. alba,which regulated 32 core targets such as MAPK8,AKT1,VEGFA,IL6 and PPARG.The targets are mainly related to acute inflammatory response,organic nitrogen compounds reaction,cell proliferation regulation,insulin stimulation response and other biological processes.It can play a role in the treatment of diabetes through interleukin-17 signaling pathway,tumor necrosis factor signaling pathway,PI3K-Akt signaling pathway and MAPK signaling pathway.In this study,we analyzed the active component groups and action mechanism of different parts of M. alba in the prevention and treatment of diabetes mellitus through network pharmacology,and provided a reference basis for the relationship between the different parts of M. alba in the prevention and treatment of diabetes.