Ginseng (Panax ginseng C.A.Meyer) is one of the most common Chinese medicinal materials.Rare ginsenosides,such as  Rg₃,etc,which are the important physiologically active substances from the ginseng plant with significant effects of the anti-tumor and anti-fatigue.The synthesis and transformation methods of ginsenoside Rg₃ have gradually evolved from the traditional decoction method to today's diversified transformation methods,the main researches focus on thermal cracking,acid and alkali hydrolysis,enzymatic hydrolysis and microbial transformation methods.In order to provide some bases for further research on the synthesis and transformation of rare ginsenoside Rg₃,this article reviewed the research status and progresses of ginsenoside Rg₃.