Aspergillus is one of the most common and important sources of bioactive natural products.However,the number of new secondary metabolites from Aspergillus stains has become fewer in recent years.In order to overcome this trend,this work firstly makes a comprehensive survey of chemical diversity of Aspergillus using “one strain many compounds” (OSMAC) strategy and evokes their bisynthetic gene clusters (BGCs) on basis of extensive literature search.It not only provides an important basis for further exploring novel secondary metabolites from Aspergillus strains,but also supplies a key reference for deeply utilization of other well studied microorganisms.