To investigate the effects of different drying methods on the appearance and internal quality of cultivated Fritillaria cirrhosa D.Don (CFC) by using intuitive analysis, cluster analysis (HCA) and principal component analysis (PCA). Results indicated that traditional sun-dried CFC has better appearance, white surface color, enough cross section mealiness, and high content of effective ingredients, but the drying rate was slow and vulnerable to the environment impact, while the drying rate of hot air drying was faster and the time was shortened. When the temperature was 50-55 ℃, the appearance of CFC was similar to that of the sun drying method, except for the content of total starch, the extract and total alkaloids all increased. However, in the fixation treatment and the 60 ℃ treatment, the cross section mealiness was weakened, degree of keratinization was increased, which also promoted the decomposition of starch, the starch content was reduced by 33.6% and 26.25% compared with the traditional drying method. The surface color of freeze-dried medicinal material was off-white, and the internal texture was loose and porous, and the texture became lighter, the content of total alkaloids and total starch was highest (0.191% and 70.37%, respectively). Comprehensive analysis showed that 50-55 ℃ hot air drying method are better than sun drying method, and can be popularized and applied in the processing of CFC in production place; in the freeze-drying method, the content of active ingredients is high, and it can be used for extraction of medicinal effective ingredients.