Asari Radix et Rhizoma (ARR) is the dried roots and rhizomes of Asarum heterotropoides Fr.Schmidt var. mandshuricum (Maxim.) Kitag., Asarum sieboldii Miq.var. seoulense Nakai or Asarum sieboldii Miq.in the Aristolochiaceae plants,it mainly contains volatile oils,lignans,flavonoids,polysaccharides and other chemical components.Modern pharmacological and clinical studies have shown that ARR has many pharmacological activities,such as analgesic and anti-inflammatory,antioxidant,antibacterial,antitussive,antiasthmatic,antidepressant responses,tumor suppression,blood suppression.It has been used for the treatment of diseases such as anemofrigid cold,rheumatic arthralgia,multiple pain and phlegm and cough.Based on a summary of the chemical constituents and pharmacological effects of ARR,combining with the research actuality,the quality marker (Q-Marker) was predicted from the aspects of kinship,characteristic composition,effectiveness,pharmacokinetics,chemical composition measuability and compatibility of traditional Chinese medicine.It was predicted that aristolochic acid Ⅳa,methyl eugenol,safrole,L-asarbon,L-sesamin,2-methoxy-4-vinylphenol,trimethoxy toluene,1,8-cineulin,β-asarbon,kakuol,caribine,kaempferol and etc.could be used as the candidate compounds for the quality markers of ARR,in order to provide a reference for the establishment of quality standard,in-depth study and comprehensive utilization of ARR.