Flavonoids are common phytochemicals in nature.They have a variety of physiological activities and functions，and they have been widely used in food,medicine and other fields.However,the role of natural flavonoids played is limited,and the functional effect is not significant when acting alone.Therefore,enhancing the effect of flavonoids is an urgent problem to be solved.This paper summarizes the experimental progress of flavonoids in synergy with other natural molecules in nature,summarizes the evaluation methods to determine whether there is synergy,and discusses the relevant mechanism of synergistic effect,in order to provide a reference for the development of natural functional food and medicine based on flavonoids.