Using transcriptomics,network pharmacology,and molecular docking techniques to predict the active components,targets,and mechanisms of Schisandrae Chinensis Fructus (SCF)and Lycii Fructus (LF) in protecting against radiation-induced liver injury.The main active components of SCF and LF were selected through traditional Chinese medicine systems pharmacology database and analysis platform(TCMSP),14 active components were selected from SCF,and 25 active components were selected from LF.The core components were mainly quercetin,glycitein and arnebin 7;The target genes for radiation injury were obtained through genecards and online human mendelian genetic database,and the obtained genes were corrected by UniProt,a total of 66 key targets were found.A drug-active component-key target-radiation liver injury control network was constructed using cytascape software,and the targets for active components and diseases were uploaded to the string database,Construct a drug target protein radiation liver injury protein interaction network,and select the key core targets as CASP3,EGFR,and ESR1 based on the degree value;The function enrichment analysis and pathway enrichment analysis of key targets were carried out,The active components of SCF and LF were mainly involved in chemical carcinogenesis receptor activation,lipid and arterial atherosclerosis,PI3K-Akt,MAPK,apoptosis,etc;Molecular docking results suggest that the three active components have strong binding ability to target proteins.This study preliminarily found that SCF and LF may play a protective role in radiation-induced liver injury by regulating chemical carcinogenesis receptor activation,lipid and arterial atherosclerosis,PI3K-Akt,MAPK,apoptosis and other signaling pathways through quercetin,glycitein and arnebin 7.

"> Schisandrae Chinensis Fructus, Lycii Fructus, radiation-induced liver injury, transcriptomics, network pharmacology, molecular docking