To study the chemical constituents of the whole plant of Lespedeza forrestii.The compounds were isolated and purified by various modern chromatographic techniques,including Sephadex LH-20 column chromatography and preparative HPLC,and their structures were characterized predominantly on the basis of NMR and MS spectroscopic data.Ten compounds were isolated from the MeOH extract of L. forrestii.The isolated compounds were identified as kaempferol-3-O-α-L-rhamnoside(1),quercetin-3-O-α-L-rhamnoside (2),kaempferol-3-O-rutinoside (3),quercetin-3-O-rutinoside (4),kaempferol-3-O-robinobioside (5),vitexin (6),orientin (7),vicenin-2 (8),genistein (9),and dalbergioidin (10).Compounds 1-10 were isolated from  L. forrestii for the first time.Compounds 1-10 were screened for anti-inflammatory activity in LPS-induced RAW264.7 cells.At a concentration of 20 μmol/L,compounds 8 and 10 showed inhibitory effect on the mRNA expression of IL-6 and IL-1β,respectively.