This study aims to investigate the chemical constituents from the leaves Ficus equiroliana H.Lév,together with their α-glucosidase inhibitory activities.Nine compounds were isolated and purified from the 95% ethanol extract of the title plant by using systematic separation methods,including silica gel,ODS,Sephadex LH-20  column chromatography  and semi-preparative liquid chromatography.Their structures were identified as N-trans-ferulic-L-proline methyl ester (1),N-p-coumaroyltyramine (2),3′,4′,5′-trimethoxycinnamyl alcohol (3),lcariside H₁ (4),(-)-dendrolactone (5),3-hydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl)-1-propanone (6),trans-ferulic acid (7),sinapyl alcohol (8) and (E)-p-coumaric acid (9) by NMR and HR-ESI-MS.Compound 1 is a new compound,compounds 2-6 and 8 were isolated for the first time from the leaves of F. equiroliana.Compounds 1-6 and 8 showed α-glucosidase inhibitory activities with IC₅₀ values of 76.25-263.18 μmol/L.