This study aims to explore the potential mechanism of Lifei tablets in the treatment of chronic bronchitis through network pharmacology and molecular docking methods. CMSP, OMIM and DisGent databases were used to find the active components and gene targets for chronic bronchitis.STRING and MetaScape platforms were used to construct the protein interaction (PPI) network and the active ingredient-common target-signal pathway network of Lifei Tablet for the treatment of chronic bronchitis.A total of 128 active ingredients,531 active ingredient related targets,174 disease related targets,and 33 intersection targets were obtained.There were ten core therapeutic targets.The intersection targets were analyzed,among which 2 548 biological processes,191 molecular functions and 97 cell compositions were obtained by GO enrichment analysis. In summary,Lifei tablets may regulate targets such as TNF,TP53,CXCL8,IL1B,IL6,IL4,IL1 and CD4,and participate in the synthesis and transport of cytoplasmic regulatory factors,thereby controlling cell proliferation and apoptosis to improve the condition of chronic bronchitis.