Abstract: Waterinsoluble drug for coronary heart disease (CHD),quercetin,was incorporated in MCM-41 channel by using in situ self-assembly method.The assembling materials were characterized by XRD,SEM and FT-IR techniques.The experimental results proved that drug assembling rate was 93% ［m(drug)/m(total drug)］,much higher than post-assembly method (70%).The release rate of the assemblies was 93% after around 13 h,which was measured in the artificial intestinal fluid.It was also higher than results of post-assembly drug system (87.25%).The results indicated that in-situ self-assembling quercetin/MCM-41 was an ideal system to prepare a controlled-release delivery system.

Key words: MCM-41, quercetin, in-situ assemble, release efficiency