Abstract: In this study,the hemostasis convergence effect of Agrimonia pilosa Ledeb(including:fresh leaves and dried leaves powder containing lysozyme)on the healing of damage model and burn model rat was studied.The function of sterilization of A.pilosa extract on 3 common pathogenic bacteria including Staphylococcus epidermidis, Escherichia coli and Pseudomonas aeruginosa was investigated.The results showed that the wound healing effect of the fresh A.pilosa was higher than that of dried powder,but slightly lower than that of Yunnan Baiyao powder.The addition of lysozyme did not affect the healing ability of dried powder to rat wound but significantly prolonged its storage time.From these results,it was concluded that both fresh and dried powder can improve hemostasis convergence,while the fresh powder was better than the dried one.Antibacterial experiment showed that the crude extract of A.pilosa can strongly inhibit the growth of S.epidermidis and E.coli, but not for P.aeruginosa. These results demonstrated that active gradient,which existed in the fresh leaves of A.pilosa, showed the anti-bacterial ability.The addition of lysozyme can prolong the storage time of A.pilosa powder.

Key words: Agrimonia pilosa, damage model, hemostasis convergence, antimicrobial effect