Abstract: To study the effects of mangiferin on the inflammatory response,the activation of monocytes and the expression of inflammatory factors in serum of spontaneously hypertensive rats(SHR),to learn more about the role of mangiferin for resisting hypertension of chronic inflammation and its mechanism.Tail artery systolic pressure was measured by fully automatic noninvasive blood pressure measurement system;The total numbers of whole blood leukocyte were counted by cell-count boards;the chemotaxis numbers of peripheral blood mononuclear cells were counted by chemotaxis test and the levels of monocyte chemotaxis factor-1(MCP-1),tumor necrosis factor alpha(TNF-α),interleukin 6(IL-6)and interleukin 10(IL-10)in rat serum were measured by using ELISA.In the three time points of before and after drug administration,the blood pressure in model group was significantly higher than the normal control group(P<0.01),and the blood pressure in each dose mangiferin group was lower than that in model group respectively,but with no statistical significance(P>0.05);High dose mangiferin can significantly decrease the total numbers of whole blood leukocytes in the model group(P<0.05);High and low dose mangiferin can significantly decrease the number of monocyte chemotaxis in the model group(P<0.05);Each dose of mangiferin can decrease the content of MCP-1 in the model group(P<0.05);Low dose mangiferin significantly reduced the content of TNF-a in the model group(P<0.05);Medium and low dose mangiferin significantly increased the content of IL-10 in the model group(P<0.01).There was obvious inflammatory reaction in SHR,mangiferin had no obvious pharmacodynamics of hypotensive of SHR,but it had obvious anti-inflammatory effect,its mechanism was possibly related to the inhibition of activation of monocytes and the expression of inflammatory cytokines.

Key words: mangiferin, spontaneously hypertensive rat, inflammation, activation of monocyte, inflammatory factor