Abstract: Taking the initial adhesion,forming property and comprehensive sense as evaluation indexes to optimize the matrix formulation of Compound Duyiwei Gel Plasters.Using the rheological property as evaluation indexes to screen the drug loading.Calendering processing was used to prepare Compound Duyiwei Gel Plasters,and the process parameters,including the material adding order,stirring speed and time,drying temperature and time,were investigated.The preferred matrix formulation was as follows:ViscomateTM NP700 5.0 g,Aluminium glycinate 0.14 g,glycerol 25 g,EDTA 0.2 g,and the drug loading was 84 g fluid extract.The compound Duyiwei gel plasters prepared by the optimized prescription and preparation technique was smooth,with appropriate adhesion and without residual behavior,and was feasible for following the skin.

Key words: Compound duyiwei gel plasters, Box-Behnken design, matrix formulation, rheological property