Synthesis of 10Hydroxycamptothecin and Its New Derivatives

doi:10.16333/j.10016880.2016.S.012

Abstract

Abstract: This essay studied with camptothecin as raw materials,synthesized 10hydroxy camptothecin by illumination method,and then has obtained N ethoxycarbonyl S proline is reacted with HCPT synthesized its new derivatives 10 prolinecamptothecin,its structure was characterized by 1HNMR. The results showed that HCPT 63% yield,10 prolinecamptothecin's is 53.8%. The new composition of the proline and camptothecin anticancer therapy may play a synergistic effect.

Key words: synthesis, 10hydroxycamptothecin, antitumor activity, 10prolinecamptothecin

CLC Number:

DAI Hansong*,LUO Guiwen,DENG Long,LUO Hong,LIU Zhengli. Synthesis of 10Hydroxycamptothecin and Its New Derivatives[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2016, 28(增刊2): 244-246.

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Synthesis of 10Hydroxycamptothecin and Its New Derivatives

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