Abstract: To evaluate the rehabilitation effects of Benincasa hispida extract on sunburn mice skin by urtraviolet radiation.The mice model was developed by UV radiation,and the model mice were divided into normal control,negative control,positive control (lidocaine) and experimental group (freeze drying group) randomly.The mice in positive control and experimental group were applied with lidocaine and B.hispida extract twice a day respectively,both normal group and negative group were applied with saline twice a day.Then,executed the mice on 0,1,3,7,14 d respectively.The back skin was separated to make biopsy and western-blot assay.The expressions of growth factor of VEGF and FGF-2 were higher in positive control and experimental group than those in other groups,and significant difference was detected between negative control group and experimental group.The pathological analysis results showed that the number of blood vessels,fiber cells and fibroblasts in experimental group was significantly higher than those in negative group. B.hispida extract enhanced the expressions of VEGF and FGF-2,and promoted wound healing.

Key words: Benincasa hispida extract, ultraviolet, VEGF, FGF-2