A New Isoquinoline Alkaloids from Stem Barks of Cassia alata and Its Cytotoxicity

doi:10.16333/j.1001-6880.2016.10.003

NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2016, Vol. 28 ›› Issue (10): 1517-1519. doi: 10.16333/j.1001-6880.2016.10.003

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A New Isoquinoline Alkaloids from Stem Barks of Cassia alata and Its Cytotoxicity

ZHOU Ling1,2,MA Hang-ying2,YANG Yan2,XING Huan-huan2,YE Yan-qing1,2,HU Qiu-fen2,ZHOU Min2,LI Jian-gang2,3*

1 School of Chemistry & Environment,Yunnan Minzu University; 2 Key Laboratory of Chemistry in Ethnic Medicinal Resources,State Ethnic Affairs Commission & Ministry of Education,Yunnan Minzu University,Kunming 650500,China;3 Anesthesiology in the Qujing First People’s Hospital,Qujing 655000,China

Online:2016-10-31 Published:2017-03-30

Abstract

Abstract: A new isoquinoline alkaloids (1),has been isolated from the bark of Cassia alata by using various chromatographic techniques.Compound 1 is a new compound,determined as 3-hydroxy-1-(7-hydroxy-6-methoxyisoquinolin-1-yl)propan-1-one,and it displayed cytotoxicity against NB4,A549,SHSY5Y,PC3 and MCF7 cell lines with IC₅₀ values of 2.2,1.6,3.8,5.3 and 1.6 μM,respectively. 

Key words: Dai medicine, Cassia alata L, isoquinoline alkaloids, cytotoxic activity

CLC Number:

R284.2

ZHOU Ling1,2,MA Hang-ying2,YANG Yan2,XING Huan-huan2,YE Yan-qing1,2,HU Qiu-fen2,ZHOU Min2,LI Jian-gang2,3*. A New Isoquinoline Alkaloids from Stem Barks of Cassia alata and Its Cytotoxicity[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2016, 28(10): 1517-1519.

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A New Isoquinoline Alkaloids from Stem Barks of Cassia alata and Its Cytotoxicity

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