Abstract: To study the chemical constituents and their cytotoxic activity from Streptomyces sp.B170167,which was isolated from soil of Yantai Beach.11 Nitrogencontaining compounds were purified by means of chromatographic techniques and their structures were identified on the basis of spectral features.Cytotoxic activity was performed by the brine shrimp (Artemia salina) larvae bioassay.9 Indole derivate compounds,named Turbomycin A (1),3,3-Bis(3-indolyl)propane-1,2-diol (2),N-(2-(1H-Indol-3-yl)-2-oxoethyl)-acetamide (3),N-Acetyltryptophan (4),Harman (5),Indole-3-carboxaldehyde (6),3-Indolepropionic acid (7),Indole-3-carboxylic acid (8),Lumichrome (9),Ferrioxamine E (10) and 2-Methylpyridin-3-ol (11),were isolated from the organic extract of fermentation broths of the Streptomyces sp.B170167.Compounds 11 was first isolated from the microorganism.Compounds 1,2,5,10 and 11 showed significant cytotoxic activity against the brine shrimp larvae,and compounds 3,4,6,7 and 8 showed moderate activity.

Key words: marine Streptomyces, nitrogen containing compound, cytotoxic activity, Artemia salina