NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2016, Vol. 28 ›› Issue (10): 1612-1617. doi: 10.16333/j.1001-6880.2016.10.021

• Article • Previous Articles     Next Articles

Anti-angiogenesis Effects of 96 Compounds from Chinese Medicine

HUA Hui1,ZHANG Min2,TAO Yong-hui3*   

  1. 1 College of Pharmacy and Chemistry & Chemical Engineering,Taizhou University,Taizhou 225300,China; 2Wuxi Higher Health Vocational Technology School,Wuxi 214028,China;3Jiangsu Institute  of Parasitic Diseases,Key Laboratory of Parasitic Disease Control and Prevention (Ministry of Health), Jiangsu Provincial Key Laboratory of Parasite Molecular Biology,Wuxi 214064，China
  • Online:2016-10-31 Published:2017-03-30

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Abstract: 96 Compounds from Chinese medicine were assayed against Eahy-926 cell in vitro and 11 of them on the chorioallantoic membrane (CAM) in vivo. The results showed that 11 compounds had a dose-dependent inhibition of growth in Eahy-926 cells in vitro, and 10 of them significantly inhibited angiogenesis on CAM at a concentration of 50 μg/egg.Compounds fraxetin,tetrandrine,honokiol,dauricine,ruscogenin,galangin,genistin,4-dicaffeoylquinic acid,oleanolic acid and α-mangostin showed anti-angiogenesis activity,and were worth further studying.

Key words: compounds from Chinese medicine, high throughput screening, Eahy-926 cell

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