Abstract: Nicotiana tabacum as an important economic crop was widely grown in world.Investigating its chemical constituents and their bioactivities was very important to provide valuable clues for future research about N.tabacum. In this study,we analyzed and summarized the progress of research on chemical constituents and bioactivities of N.tabacum from 1987 to 2016 on the basis of reviewing the related papers of domestic and overseas.Diterpenoids,sesquiterpoids,flavonoids and alkaloids were the main constituents for its non-volatile components.Almost all compounds isolated from N.tabacum during 1987 to 2016 were diterpenoids and sesquiterpoids.Among those compounds of tobacco,mainly activities were diterpenoids,sesquiterpoids and alkaloids, etc, and their activities basically possessed the neuroprotective effect against the nerve damage (anti-Alzheimer's disease,affect mood and sleep),anti-tumor,anti-HBV and anti-bacterial activities.

Key words: chemical constituent, bioactivity, Nicotiana tabacum