Abstract: This study was aimed to explore the protective and immunoregulation effects of sea buckthorn Vp on mice injured by X-ray radiation.150 mice were randomly divided into 6 groups as follows:normal control group (NC),model control group (MC),positive control group (PC),Vp low-dosage group (7 mg/kg,was equal of 1g herbs),Vp medium dosage group (14 mg/kg),Vp high-dosage group (28 mg/kg).In addition to the positive control group,the other groups of mice received a one-time X-ray body of uniform illumination 5Gy.The number of red blood cells,white blood cell count,platelet count in peripheral blood of mice were then determined.The SOD and MDA activity were also determined.The indexes of thymus and spleen were calculated.It was showed that sea buckthorn Vp can significantly increase quantity of hemogram (P<0.05),activity of liver SOD (P<0.05),thymus index and spleen index (P<0.05),and decrease levels of MDA in liver(P<0.05).In conclusion,sea buckthorn Vp had significant ant-oxidant and immunoregulation effect on mice injured by X-ray radiation.

Key words: sea buckthorn Vp, X-ray, anti-radiation, immune function