Abstract: In this study,the properties of baicalein such as whitening,antioxidant,antiallergy,antibacterial and safety were evaluated using biochemical enzyme method,free radical scavenging assay,determining the minimum inhibitory concentration (MIC) and experimenting hemolysis.The results showed that the inhibition rate of tyrosinase was 60.20% (2.0 mg/mL of baicalein),the scavengingrate of DPPH· and ·OH was 95.21% and 66.69% respectively (0.1 mg/mL and 1.0 mg/mL of baicalein),and the inhibition rate of enzyme was 52.51% (10.0 mg/mL of baicalein).In addition,when the concentration of baicalein reached 1.25 mg/mL,it had inhibitory effect on the five kinds of bacteria.Its half hemolysis rate (HD₅₀) was 1.80 mg/mL,protein denaturation index (DI) was 0.34,and HD₅₀/DI (H/D) >10.The experiments proved that baicalein exhibited better performance in whitening,antioxidant,antiallergy and antibacterial effects.

Key words: baicalein, cosmetics, multiple efficiency, safety