NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2017, Vol. 29 ›› Issue (增刊1): 147-152.doi: 10.16333/j.1001-6880.2017.S.030

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Proliferation Inhibition of Phellodendron chinense Schneid Fruit Extracts on Tumor Cells and Their Mechanisms

YAN Chen1*,WANG Xing-hui2,HUANG Li-rong3,ZHANG Yun-dong1,ZHANG Wei-qing1,LUO Heng2*   

  1. 1 Anshun City People’s Hospital,Anshun 561000,China;2Key Laboratory of Chemistry  for Natural Product of Guizhou Province and Chinese Academy of Science,Guiyang 560014,China;3 Guizhou Institute of Technology Guiyang 560003,China
  • Online:2017-08-02 Published:2017-08-02

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Abstract: To study the influence of extracts from the fruits of Phellodendron chinense Schneid in tumor cells(HEL,K562,BPH1,PC3,MDA) and to explore their effects on proliferation,cell cycle and apoptosis of tumor cells.The influence of extracts from the fruits of Phellodendron chinense Schneid in proliferation of HEL,K562,BPH1,PC3,MDA cells was measured by MTT assay.Cell cycle and apoptotic rate were analyzed by flow cytometry (FCM) in HEL and BPH1 cells.Compared with the control group,the HBE and Piscidinol A could inhibit the proliferation,shorten G0/G1 (P<005) obviously 〖JP3〗and extend S of BPH1cells,but they could not induce BPH1 cells’ apoptosis.The extracts (HBE,HBP and Piscidinol A) also could inhibit the growth and induce apoptosis of HEL cells,but they had no effect on cell cycle.

Key words: Phellodendron chinense Schneid, fruit, extract, tumor