Abstract: In order to study the extraction technology and method for rhizoma polygonati polysaccharide and nuciferine from Compound Polygonatum Cyrtonema,orthogonal experiments were conducted on 3 factors and 3 levels with water extraction for the effects of the rhizoma polygonati polysaccharide and nuciferine content.The result demonstrated that the best extraction method for rhizoma polygonati polysaccharide was dried herbs pieces over 50,soak 30 min,water heating reflux 2 h.Under the condition of the process,available dry extract could be 54.81g and the yield of rhizoma polygonati polysaccharide could be 64.36%,1.15 times than the average value when 250 g dried herbs were extracted.The best extraction method for nuciferine was dried herbs pieces over100,soak 30 min,water heating reflux 3 h.Under the condition of the process,available dry extract could be 48.85 g and the yield of nuciferine could be 0.1697 mg/g,1.67 times than the average value when 250 g dried herbs were extracted.Primary and secondary order of the main factors influencing the yield of rhizoma polygonati polysaccharide was ：decoction time> herbs pieces > soaking time,while herbs pieces > decoction >soaking time for nuciferine.

Key words: Compound Polygonatum Cyrtonema, Rhizoma Polygonati Polysaccharide, nuciferine, water extraction, ethanol extraction, technology