NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2017, Vol. 29 ›› Issue (7): 1136-1140.doi: 10.16333/j.1001-6880.2017.7.010

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N-containing Compounds of Marine-derived Fungus Aspergillus sp.SCSIO 41501

MA Xuan1,2,NONG Xu-hua1,HUANG Zhong-hui1,2,LIANG Xiao1,2,WANG Jie1,QI Shu-hua1*   

  1. 1 Key Laboratory of Marine Bio-resources Sustainable Utilization,Guangdong Key Laboratory of Marine MateriaMedica,Research Center for Marine Microbes,South China Sea Institute of Oceanology,Chinese Academy of Science,Guangzhou 510301,China; 2 Graduate University of the Chinese Academy of Sciences,Beijing 100049,China
  • Online:2017-07-29 Published:2017-08-11

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Abstract: Eleven N-containing compounds were isolated from a culture broth of the fungal strain Aspergillus sp.SCSIO 41501 isolated from the China South Sea gorgonian Melitodessquamata. They were identified as13-(S)-ochratoxin A (1),13-(S)-ochratoxin A methyl ester (2),13-(R)-ochratoxin A (3),4-(R)-OHochratoxin A (4),18-OH-ochratoxin A (5),transtorine (6),quinolactacin C1(7),marinamide(8),methyl Marinamide(9),aspergilliamide(10),and anoectochine(11) on the basis of spectroscopic analyses (1D NMR and ESI-MS) and by comparison of the NMR data with literatures.All the compounds were tested for their antibacterial activity.Compounds2and 3showed moderateantibacterial activity against Escherichia coli, Bacillus subtilis and Staphylococcus aureus with MIC values of 31.25,7.8,15.6 μg/mL for 2,and 62.5,31.25,62.5 μg/mL for 3,respectively.

Key words: marine fungus, Aspergillus sp.SCSIO 41501, secondary metabolism