NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2017, Vol. 29 ›› Issue (12): 2004-2009.doi: 10.16333/j.1001-6880.2017.12.002

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Water Soluble Compounds from Periplaneta americana and Their Angiogenesis Activity  

WANG Xin-long1#,XIANG Bin1#,LI Ya-mei1,GENG Fu-neng2*,YAN Yong-ming3,CHENG Yong-xian1,3*     

  1. 1State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,China; 2Sichuan Key Laboratory of Medical American cockroach,Chengdu 610000,China; 3School of Pharmacy,Shenzhen University Health
    Science Center,Shenzhen 518060,China
  • Online:2018-01-04 Published:2018-01-09

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Abstract: Twenty-twocompoundswere isolatedfrom Periplaneta americana.Their structures were identified as glycerol (1),salicylic acid (2),phenylalanine (3),tryptophan (4),uracil (5),adenine (6),cyclo(Pro-Thr) (7),cyclo(Pro-Ala) (8),cyclo (Ala-Val) (9),cyclo(Gly-Ile) (10),cyclo(Gly-Leu) (11),inosine (12),adenosine (13),cyclo(Leu-Ser) (14),cyclo(Phe-Ser) (15),(3S,6S)-3-phenylmethyl-6-amidocarboxymethyl-piperazine-2,5-dione,cis-cyclo (Asn-Phe) (16),cyclo(Tyr-Gly) (17),cyclo (Tyr-Ala) (18),cyclo(Tyr-Ser) (19),cyclo(Tyr-Thr) (20),cyclo(Tyr-Asp) (21) andcordyrrole A (22),respectively,by spectroscopic methods.Compounds 20 and 21 are new naturally occurring substances.In addition,compounds 7-11 and 14-22 were isolated from the title insect species for the first time.In addition,biological evaluation towards nitric oxide (NO) production and angiogenesis activity was conducted.

Key words: Periplaneta americana, cyclic dipeptides, NO production, angiogenesis activity

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