Abstract: Leptosphaeria causes blackleg of rapeseed/canola crops and brings serious yield losses in agriculture.The study on secondary metabolites produced by Leptosphaeria started very early,the isolation work was mainly related to blackleg pathogenic strains.The present study demonstrated that the secondary metabolites of Leptosphaeria were rich,furthermore,many compounds possessed novel structure and notable biological activities.Here were viewed the chemical structure and bioactivities of secondary metabolites produced by Leptosphaeria during the past 40 years to draw more attention to the fungus.

Key words: Leptosphaeria, Phoma, terpenes, polyketides, NRPS