Abstract: Hylotelephium erythrostictum was explored.Petroleumether,chloroform,ethylacetate,n-butanol and water extract are obtained,their antibacterial activity were investigated. The minimal inhibitory concentration (MIC) of 5 solvent extracts for 20 tested strains are measured by microdilution method.The ethyl acetate extract exhibit the good antibacterial activity.Furthermore,11 compounds were isolated from the ethyl acetate extracts,including apigenin (1),protocatechuic acid (2),ethyl gallate (3),4-hydroxybenzoic acid (4),gallic acid (5),diosmetin (6),kaempferol (7),4-acetyl-2-isopropyl-5-methylphenol (8),breynioside A (9),1,2,3,4-tetrahydro-1-phenyl-isoquinoline (10),1-(3,4-dihydro-1-phenyl-2(1H)-isoquinolinyl)-2-propen-1-one (11).Compounds 2,5~7 are isolated from Hylotelephium erythrostictum for the first time.Compounds 1,3,4,8~11 are isolated from genusfor the first time.

Key words: Hylotelephium erythrostictum, antibacterial activity, solvent extracts, chemical composition isolation