Abstract: To optimize extraction process of alkaloids in Salt Cortex Phellodendri by Golden section method with Dynamic Optimization,HPLC was employed to determine six alkaloids in Cortex Phellodendri,including berberine hydrochloride,magnoflorine berberubine,Phellodendrine,Pakistan,jatrorrhizine,Based on the scope detected by the single factor analysis and Golden section method,using Orthogonal experiment to optimize the ratio of material and solvent,extracting time and frequency.Then Dynamic design is used to further optimize the extraction process.Results that Optimized Golden section method with Dynamic Optimization was as following:Ultrasonic extracted twice with 25 times the amount of HCL-CH₃OH (1∶100) for extracting time of 60 mins and 10 mins;The extraction rate of berberine hydrochloride,magnoflorine berberubine,Phellodendrine,Pakistan,jatrorrhizine are 6.51,1.48,0.67,0.62,5.01,73.22 mg/g.So,Golden section method with Dynamic Optimization can be used to optimize the extraction process of Salt Cortex Phellodendri.it can be used as one of the screening methods of traditional Chinese medicine extraction process.

Key words: Salt Cortex Phellodendri, golden section method, dynamic optimization, alkaloids, extraction process.