NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2018, Vol. 30 ›› Issue (7): 1160-1165.doi: 10.16333/j.1001-6880.2018.7.011

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III Type Polyketone Compounds Produced by Streptomyces sp.FJS 31-2 from the Soil of Fanjing Mountain

QIAN Sheng-yan1,2,YANG Cai-ling3,CHEN Rong-xiang4,WU Ming-song1,LI Caiyu1,FU Shao-bin3,LIU Jian-guo1*   

  1. 1Special Key Laboratory of Oral Disease Research,Higher Education Institution in Guizhou Province,Zunyi Medical University; 2Guizhou Key Laboratory of Characteristic Microbial Research & Drug Development,Zunyi Medical University; 3school of pharmacy,Zunyi Medical University; 4Zunyi Engineering Technology Research Center of Physical and Chemical Analysis,Zunyi Medical University,Zunyi 563000,China
  • Online:2018-08-08 Published:2018-08-08

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Abstract: The article aim to research on secondary metabolites of Streptomyces sp.FJS 31-2 from the soil of special habitat Fanjing mountain,not only provide complicated novel compounds for microbial drug but also provide primer for their derivatives synthesis.The secondary metabolites of Streptomyces sp.FJS 31-2 were isolated by means of thin-layer chromatography (TLC),repeated silica column chromatography and RP-silica column chromatography.Its structure was identified on the basis of their mass spectrometry (MS) and nuclear magnetic resonance (NMR) methods.Three III type polyketone compounds obtained from the strain Streptomyces sp.FJS 31-2 and identified as 2-(2′S-hydroxypropyl)-7-hydroxychromone,Aloesone and 3,4-dihydro-3-(2-oxo-propyl)-3,6,8-trihydroxy-1(2H)-naphthalenone combing with MS and NMR.Those compounds were obtained for the first time from Streptomyces genus.

Key words: Streptomyces sp.FJS31-2, secondary metabolites, III type polyketones

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