NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2018, Vol. 30 ›› Issue (7): 1166-1169. doi: 10.16333/j.1001-6880.2018.7.012

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Study of Tricycloalternarenes from the Deep-sea Derived Fungus Alternaria tenuissma DFFSCS013 and Their Antimicrobial Activity

PAN Dong-yan1,2,HUANG Zhong-Hui1,2,LIANG Xiao1,2,MA Xuan1,QI Shu-Hua1*   

  1. 1Key Laboratory of Tropical Marine Bio-resources and Ecology,Guangdong Key Laboratory of Marine Materia Medica,Research Center for Marine Microbes,
    South China Sea Insitute of Oceanology,Chinese Academy of Science,Guangzhou 510301,China; 2Graduate University of the Chinese Academy of Sciences,Beijing 100049,China
  • Online:2018-08-08 Published:2018-08-08

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Abstract: Six known compounds were isolated from the fermentation products of the deep-sea derived fungus Alternaria tenuissma DFFSCS013.These compounds were identified as tricycloalternarene J (1),tricycloalternarene 2b (2),tricycloalternarene 1b (3),tricycloalternarene 6b (4),tricycloalternarene 3b (5),and tricycloalternarene 1a (6) by spectroscopic analyses.All of them were tested for antibacterial and antifungal activities.Only compound 5 showed obvious inhibition activity against the growth of Escherichia coli and Bacillus subtilis,while other compounds showed weak activity against indicators at 100 μg/dics.This is the first time to report the antibacterial activity of compounds 1-2 and 4-5 and the antifungal activity of 5.

Key words: deep-sea derived fungus, Alternaria tenuissma, tricycloalternarene  

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